SDB-005

SDB-005

Product Name: SDB-005 Synonyms: NA-PINAC; naphthalen-1-yl 1-pentyl-1H-indazole-3-carboxylate; SDC-00512

General Description: SDB-005 is formally described as naphthalen-1-yl 1-pentyl-1H-indazole-3-carboxylate.23 It is a synthetic, highly psychoactive molecule belonging to the indazole-3-carboxylate class of synthetic cannabinoids (SCs).2 Structurally, it is heavily related to the designer drug PB-22, differing primarily via the replacement of the indole core with an indazole core, and the substitution of the 8-hydroxyquinoline ester group with a naphthalene group.23

(Note regarding nomenclature: In early pharmacological literature, the academic code SDB-005 was originally assigned by researchers to a completely different molecule—PH-PICA.23 However, upon its emergence on the illicit designer drug market, grey-market vendors erroneously applied the SDB-005 identifier to NA-PINAC.2 Consequently, in modern forensic, toxicological, and legal databases, “SDB-005” almost exclusively refers to NA-PINAC).2

In analytical, clinical, and forensic toxicology, SDB-005 is utilized as a fundamental reference standard.2 It is essential for the calibration of analytical instrumentation (such as LC-MS/MS and GC-MS) and the development of screening methodologies to identify and quantify the substance in seized “herbal incense” blends (colloquially known as “Spice” or “K2”), adulterated materials, or biological matrices (e.g., whole blood, plasma, urine).2

Technical Information:

• CAS Number: 2180934-13-6123
• Molecular Formula: C₂₃H₂₂N₂O₂12
• Formula Weight: 358.4 g/mol12
• SMILES: O=C(OC1=C(C=CC=C2)C2=CC=C1)C3=NN(CCCCC)C4=CC=CC=C4312
• InChI Key: JBVNFKZVDLFOAY-UHFFFAOYSA-N13
• Formulation: Typically supplied as a neat white-to-off-white crystalline solid or as a certified reference material solution (e.g., 1 mg/mL or 100 µg/mL in methanol or acetonitrile).2

Biological Action: Like its structural relatives, SDB-005 acts as a potent, non-selective full agonist at both the central cannabinoid type 1 (CB₁) and peripheral cannabinoid type 2 (CB₂) receptors.2 By functioning as a full agonist (unlike the partial agonism exhibited by Δ⁹-THC from natural cannabis), it profoundly overstimulates the endocannabinoid system.2 This hyperactivation mediates intense, unpredictable, and highly dangerous psychoactive effects.2 Acute intoxication is strongly associated with severe synthetic cannabinoid toxidromes, including pronounced tachycardia, hypertension, acute synthetic cannabinoid-induced psychosis, severe agitation, seizures, and potentially fatal cardiovascular or renal emergencies.2

Regulatory and Safety Information:

• Intended Use: This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.2