4F-MPH (4-Fluoromethylphenidate)

4F-MPH is a fluorinated analog of methylphenidate used in dopamine reuptake research. Purity ≥98% (HPLC). For research purposes only.

Product Name: 4F-MPH (4-Fluoromethylphenidate) Synonyms: 4-FMPH; p-Fluoromethylphenidate; methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate

General Description: 4F-MPH is formally described as methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate. It is a synthetic, heavily psychoactive molecule belonging to the substituted phenidate class. Structurally, it is the direct 4-fluoro analogue of the widely prescribed central nervous system stimulant methylphenidate (Ritalin), differing only by the addition of a fluorine atom at the para-position of the phenyl ring. It emerged on the illicit designer drug market around 2015 as a novel psychoactive substance (NPS) sought for its highly potent and long-lasting psychostimulant properties.

In analytical, clinical, and forensic toxicology, 4F-MPH is utilized as a fundamental reference standard. It is essential for the calibration of analytical instrumentation (such as LC-MS/MS, GC-MS, and HPLC) and the development of screening methodologies to identify and quantify the substance in seized materials, adulterated illicit street drugs, or biological matrices (e.g., whole blood, plasma, urine).

Technical Information (Hydrochloride Salt):

• CAS Number: 1354631-33-6 (Hydrochloride)
• Molecular Formula: C₁₄H₁₈FNO₂ • HCl
• Formula Weight: 287.76 g/mol (Hydrochloride) / 251.30 g/mol (Freebase)
• SMILES: COC(=O)C(C1=CC=C(F)C=C1)C2CCCCN2.Cl
• InChI Key: DGEGVRRPRZOKBS-UHFFFAOYSA-N (Freebase)
• Formulation: Typically supplied as a neat white-to-off-white crystalline solid or as a certified reference material solution (e.g., 1 mg/mL or 100 µg/mL in methanol).

Biological Action: Like its parent compound methylphenidate, 4F-MPH acts as a potent monoamine reuptake inhibitor. It selectively and aggressively blocks the dopamine transporter (DAT) and the norepinephrine transporter (NET), preventing the clearance of these neurotransmitters from the synaptic cleft. Pharmacological profiles indicate that the para-fluoro substitution significantly increases the molecule’s binding affinity and efficacy at the dopamine transporter compared to methylphenidate, rendering 4F-MPH substantially more potent by weight. The clinical presentation of acute intoxication includes intense psychostimulation, euphoria, severe tachycardia, hypertension, hyperthermia, and a notable propensity for inducing severe anxiety, paranoia, and stimulant psychosis at supratherapeutic doses.

Regulatory and Safety Information:

• Intended Use: This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.
• Warning: This product is an exceptionally potent psychostimulant and carries a severe risk of intense psychological dependence, acute psychiatric crises, cardiovascular stress, and potentially fatal overdose. It is not for human or veterinary use.