A-PHP (Alpha-Pyrrolidinohexiophenone)

A-PHP (Alpha-Pyrrolidinohexiophenone)

A-PHP is a synthetic cathinone used in monoamine transporter research. Purity ≥98% (HPLC). For research purposes only.

Product Name: α-PHP (alpha-Pyrrolidinohexiophenone) Synonyms: a-PHP; PV-7; 1-phenyl-2-(pyrrolidin-1-yl)hexan-1-one; alpha-pyrrolidinohexanophenone

General Description: α-PHP is formally described as 1-phenyl-2-(pyrrolidin-1-yl)hexan-1-one. It is a synthetic, highly psychoactive molecule belonging to the cathinone class, specifically the pyrrolidinophenone subclass. Structurally, it is a higher homologue of the notorious designer drug α-PVP (colloquially known as “Flakka”), differing only by the extension of the alkyl side chain from a pentyl to a hexyl group. α-PHP emerged on the illicit designer drug market in the mid-2010s as a novel psychoactive substance (NPS) specifically intended to circumvent international legislation controlling α-PVP and MDPV.

In analytical, clinical, and forensic toxicology, α-PHP is utilized as a fundamental reference standard. It is essential for the calibration of analytical instrumentation (such as LC-MS/MS, GC-MS, and HPLC) and the development of screening methodologies to identify and quantify the substance in seized materials, adulterated illicit street drugs, or biological matrices (e.g., whole blood, plasma, urine).

Technical Information (Hydrochloride Salt):

• CAS Number: 13415-86-6 (Hydrochloride)
• Molecular Formula: C₁₆H₂₃NO • HCl
• Formula Weight: 281.82 g/mol (Hydrochloride) / 245.36 g/mol (Freebase)
• SMILES: CCCCC(N1CCCC1)C(=O)C2=CC=CC=C2.Cl
• Formulation: Typically supplied as a neat white-to-off-white crystalline solid or as a certified reference material solution (e.g., 1 mg/mL or 100 µg/mL in methanol).

Biological Action: Like its structural relative α-PVP, α-PHP acts as a profoundly potent monoamine reuptake inhibitor. It selectively and aggressively blocks the dopamine transporter (DAT) and the norepinephrine transporter (NET), while exhibiting negligible affinity for the serotonin transporter (SERT). This massive accumulation of dopamine and norepinephrine in the synaptic cleft mediates its intense and short-acting psychostimulant effects. The clinical presentation of acute α-PHP intoxication includes intense euphoria, severe tachycardia, hypertension, hyperthermia, extreme agitation, and a high propensity for inducing prolonged stimulant psychosis, severe paranoia, and excited delirium.

Regulatory and Safety Information:

• Intended Use: This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.
• Warning: This product is an exceptionally potent psychostimulant and carries a severe risk of intense psychological dependence, acute psychiatric crises, cardiovascular collapse, and potentially fatal overdose. It is not for human or veterinary use.
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