Flubromazolam is a potent triazolobenzodiazepine for GABA-A receptor research. Purity ≥98% (HPLC).

Product Name: Meclonazepam Synonyms: 3-Methylclonazepam; Ro 11-3128; 5-(2-chlorophenyl)-3-methyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one12

General Description: Meclonazepam is a synthetic, psychoactive molecule belonging to the benzodiazepine class.135 Structurally, it is heavily related to the widely prescribed pharmaceutical clonazepam, differing only by the addition of a methyl group at the 3-position of the diazepine ring.23 Originally synthesized by Hoffmann-La Roche in the 1970s, it is a highly unique compound that was investigated not only for its sedative and anxiolytic properties but also for distinct anti-parasitic (schistosomicidal) effects.245 Ultimately, its profound sedating nature precluded its clinical viability as an antiparasitic drug.235 More recently, meclonazepam has emerged on the illicit market as a novel psychoactive substance (NPS) and designer benzodiazepine.245

In analytical, clinical, and forensic toxicology, meclonazepam is utilized as a fundamental reference standard.235 It is essential for the calibration of analytical instrumentation (such as LC-MS/MS, GC-MS, and NMR) and the development of screening methodologies to identify and quantify the substance in seized materials, adulterated illicit street drugs, or biological matrices (e.g., whole blood, plasma, urine).14

Flubromazolam Technical Information:

CAS Number: 58662-84-3 (S-enantiomer) / 67027-56-9 (Racemic mixture)24
Molecular Formula: C16H12ClN3O345
Formula Weight: 329.74 g/mol45
SMILES: CC1C(=O)NC2=C(C=C(C=C2)N+[O-])C(=N1)C3=CC=CC=C3Cl
InChI Key: LMUVYJCAFWGNSY-UHFFFAOYSA-N (Racemate) / LMUVYJCAFWGNSY-VIFPVBQESA-N (S-enantiomer)14
Formulation: Typically supplied as a neat white-to-yellow crystalline solid or as a certified reference material solution (e.g., 1 mg/mL or 100 µg/mL in methanol).145

Biological Action: Meclonazepam acts as a highly potent positive allosteric modulator (PAM) at central GABAA receptors.145 By enhancing the inhibitory signaling of the neurotransmitter gamma-aminobutyric acid (GABA), it elicits classical benzodiazepine effects, including profound sedation, anxiolysis, hypnosis, muscle relaxation, and amnesia.24 Separately from its GABAergic activity, meclonazepam uniquely induces rapid intracellular calcium influx and spastic paralysis in the parasitic worm Schistosoma mansoni (the causative agent of schistosomiasis), leading to tegumental disruption and parasite death.245

Flubromazolam Regulatory and Safety Information:

Intended Use: This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.135
Warning: This product is highly potent, carries a severe risk of central nervous system depression, physiological dependence, and fatal overdose (especially when combined with other depressants like alcohol or opioids).145 It is not for human or veterinary use.456