3-FEA (3-Fluoroethamphetamine)

3-FEA (3-Fluoroethamphetamine)
Product Name: 2-FMA (2-Fluoromethamphetamine) Synonyms: o-Fluoromethamphetamine; ortho-Fluoromethamphetamine; 1-(2-fluorophenyl)-N-methylpropan-2-amine

General Description: 2-FMA is formally described as 1-(2-fluorophenyl)-N-methylpropan-2-amine. It is a synthetic, psychoactive molecule belonging to the substituted amphetamine class. Structurally, it is the 2-fluoro (or ortho-fluoro) analogue of the heavily regulated central nervous system stimulant methamphetamine. 2-FMA emerged on the illicit designer drug market in the early 2010s as a novel psychoactive substance (NPS). Within grey-market communities, it gained popularity as a “functional” stimulant due to user reports suggesting it lacks the profound euphoria of methamphetamine or 4-FA, instead presenting with a profile more comparable to prescription amphetamines like dextroamphetamine or lisdexamfetamine.

In analytical, clinical, and forensic toxicology, 2-FMA is utilized as a fundamental reference standard. It is essential for the calibration of analytical instrumentation (such as LC-MS/MS, GC-MS, and HPLC) and the development of screening methodologies to identify and quantify the substance in seized materials, adulterated illicit street drugs, or biological matrices (e.g., whole blood, plasma, urine).

Technical Information (Hydrochloride Salt):

• CAS Number: 1017176-48-5 (Hydrochloride)
• Molecular Formula: C₁₀H₁₄FN • HCl
• Formula Weight: 203.7 g/mol (Hydrochloride) / 167.22 g/mol (Freebase)
• SMILES: CC(CC1=CC=CC=C1F)NC.Cl
• InChI Key: HKEKBDQSTSVDKM-UHFFFAOYSA-N (Freebase)
• Formulation: Typically supplied as a neat white-to-off-white crystalline solid or as a certified reference material solution (e.g., 1 mg/mL or 100 µg/mL in methanol).

Biological Action: Like its parent compound methamphetamine, 2-FMA acts primarily as a potent monoamine releasing agent and reuptake inhibitor. It actively reverses the transport direction of the dopamine transporter (DAT) and the norepinephrine transporter (NET), forcing the massive release of these stored catecholamines into the synaptic cleft. Unlike its structural isomer 4-FMA (4-fluoromethamphetamine), which exhibits notable serotonergic activity (entactogenic effects), 2-FMA has relatively weak affinity for the serotonin transporter (SERT). This specific pharmacological profile strongly mediates its classical psychomotor stimulant effects, which include pronounced wakefulness, increased focus, tachycardia, hypertension, and appetite suppression.

Regulatory and Safety Information:

• Intended Use: This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.
• Warning: This product is a potent psychostimulant and carries a significant risk of central nervous system overstimulation, cardiovascular stress, severe anxiety, and physiological dependence. It is not for human or veterinary use.