MAM-2201

Product Name: MAM-2201 Synonyms: 4′-methyl-AM-2201; 5-fluoro-JWH-122; 1-(5-fluoropentyl)-1H-indol-3-ylmethanone

General Description: MAM-2201 is formally described as 1-(5-fluoropentyl)-1H-indol-3-ylmethanone. It is a synthetic, highly psychoactive molecule belonging to the naphthoylindole class of synthetic cannabinoids (SCs). Structurally, MAM-2201 is a rationally designed hybrid of two well-known, first-generation synthetic cannabinoids: it combines the 5-fluoropentyl N-alkyl chain found in AM-2201 with the 4-methylnaphthoyl group found in JWH-122. It emerged heavily on the illicit designer drug market around 2011–2012 as a novel psychoactive substance (NPS) and active ingredient in “herbal incense” smoking blends.

In analytical, clinical, and forensic toxicology, MAM-2201 is utilized as a fundamental reference standard. It is essential for the calibration of analytical instrumentation (such as LC-MS/MS and GC-MS) and the development of screening methodologies to identify and quantify the substance in seized materials, adulterated products, or biological matrices (e.g., whole blood, plasma, urine).

Technical Information:

• CAS Number: 1354611-28-7
• Molecular Formula: C₂₅H₂₄FNO
• Formula Weight: 373.47 g/mol
• SMILES: FCCCCCN1C=C(C2=C1C=CC=C2)C(=O)C3=C4C=CC=CC4=C(C)C=C3
• InChI Key: UWHMQXUSGYPUDT-UHFFFAOYSA-N
• Formulation: Typically supplied as a neat white-to-off-white crystalline solid or as a certified reference material solution (e.g., 1 mg/mL or 100 µg/mL in methanol or acetonitrile).

Biological Action: Like its parent compounds, MAM-2201 acts as a highly potent, non-selective full agonist at both the central cannabinoid type 1 (CB₁) and peripheral cannabinoid type 2 (CB₂) receptors. Preclinical receptor binding assays indicate its affinity for the CB₁ receptor is exceptionally high, heavily surpassing that of Δ⁹-THC (the primary psychoactive component of natural cannabis). Because it functions as a full agonist rather than a partial agonist, it profoundly overstimulates the endocannabinoid system. Acute intoxication is notoriously associated with severe synthetic cannabinoid toxidromes, including pronounced tachycardia, hypertension, intense paranoia, acute synthetic cannabinoid-induced psychosis, severe agitation, seizures, and potentially fatal cardiovascular or renal emergencies.

Regulatory and Safety Information:

• Intended Use: This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.
• Warning: This product is an exceptionally potent synthetic cannabinoid and carries a severe risk of psychiatric crises, neurological emergencies (including seizures), and potentially fatal overdose. It is not for human or veterinary use.