25I-NBOMe Blotter

25I-NBOMe blotter papers. Accurately dosed research chemical. For laboratory research only.

Product Name: 25I-NBOMe (2C-I-NBOMe) Synonyms: 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine; NBOMe-2C-I; Cimbi-5; Smiles

25I-NBOMe Blotter General Description:

25I-NBOMe is formally described as 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine. It is a synthetic, exceptionally potent, highly psychoactive molecule belonging to the N-benzylmethoxy derivative (NBOMe) class of substituted phenethylamines. Originally synthesized in 2003 for academic use in mapping serotonin receptors in the brain, it emerged on the illicit designer drug market in the early 2010s.

In forensic toxicology and law enforcement casework, 25I-NBOMe is most notoriously encountered dosed onto blotter paper (perforated sheets). Because it is active in the sub-milligram (microgram) range, illicit distributors frequently laid 25I-NBOMe onto blotters and falsely sold it as LSD (lysergic acid diethylamide). This deceptive practice has been the direct cause of numerous mass-casualty events and fatal overdoses, as 25I-NBOMe possesses a radically different and far more dangerous toxicological profile than LSD.

In analytical laboratories, the pure reference standard is essential for the extraction, identification, and quantification of the substance from seized blotter papers or biological matrices (e.g., whole blood, post-mortem tissues).

Technical Information (Hydrochloride Salt): 25I-NBOMe Blotter

• CAS Number: 1043868-97-8 (Hydrochloride) / 919797-19-6 (Freebase)
• Molecular Formula: C₁₈H₂₂INO₃ • HCl
• Formula Weight: 463.7 g/mol (Hydrochloride) / 427.28 g/mol (Freebase)
• SMILES: COC1=CC=CC=C1CNCCC2=CC(OC)=C(I)C=C2OC.Cl
• InChI Key: OGNZRVWKXDFKLG-UHFFFAOYSA-N (Freebase)
• Analytical Formulation: While illicitly encountered as a blotter, certified reference standards for laboratory use are strictly supplied as a neat white-to-off-white crystalline solid or as a highly dilute, certified reference material solution (e.g., 1 mg/mL or 100 µg/mL in methanol). Legitimate chemical suppliers do not formulate or distribute reference standards on blotter paper.

Biological Action: Unlike classical psychedelics such as LSD or psilocin (which act as partial agonists), 25I-NBOMe acts as a highly selective, extraordinarily potent full agonist at the serotonin 5-HT_2A receptor. It exhibits a binding affinity (K_i) in the low nanomolar-to-picomolar range. Because it is a full agonist, it completely lacks the physiological “ceiling effect” of classical psychedelics. Acute intoxication is notoriously dangerous and highly dose-sensitive. Severe toxidromes include profound systemic vasoconstriction, severe tachycardia, extreme hypertension, hyperthermia, seizures, serotonin syndrome, acute kidney injury, and fatal cardiovascular or respiratory collapse.

Regulatory and Safety Information:

• Intended Use: This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.
• Warning: This product is exceptionally potent and highly toxic in microgram quantities. Ingestion of 25I-NBOMe blotters carries a severe, documented risk of fatal overdose. It is not for human or veterinary use.