2C-E

**Product Name:**

2C-E (4-Ethyl-2,5-dimethoxyphenethylamine) **Synonyms:** 2,5-Dimethoxy-4-ethylphenethylamine; Aquarust **General Description:** 2C-E is formally described as 2-(4-ethyl-2,5-dimethoxyphenyl)ethan-1-amine. It is a synthetic, psychoactive molecule belonging to the phenethylamine class and the 2C family of ring-substituted phenethylamines, originally synthesized by Alexander Shulgin. Pharmacologically, 2C-E acts as a potent agonist at serotonin receptors. In analytical, clinical, and forensic toxicology, 2C-E is utilized as a reference standard for the calibration of analytical instruments (such as LC-MS/MS and GC-MS) and the development of screening methods to identify and quantify designer drugs in seized materials or biological matrices.

**Technical Information
(Hydrochloride Salt):** * **CAS Number:** 923013-67-6 (Hydrochloride) / 71539-34-9 (Freebase) * **Molecular Formula:** C₁₂H₁₉NO₂ • HCl * **Formula Weight:** 245.7 g/mol * **SMILES:** COC1=C(CCN)C=C(OC)C(CC)=C1.Cl * **InChI Key:** CTDRFXSMYFXGIH-UHFFFAOYSA-N (HCl salt) / VDRGNAMREYBIHA-UHFFFAOYSA-N (Freebase) *

**Formulation:** Typically supplied as a neat crystalline solid or as a 1 mg/mL solution in methanol.

**Biological Action:**

2C-E acts predominantly as an agonist at serotonin 5-HT_2A and 5-HT_2C receptors. The activation of the 5-HT_2A receptor is highly correlated with its psychedelic effects. Unlike some other phenethylamine derivatives, 2C-E has negligible activity as a monoamine releasing agent or monoamine reuptake inhibitor. In vivo, it is noted for having a remarkably steep dose-response curve, meaning minor increases in dosage can yield disproportionately large pharmacological effects.

**Regulatory and Safety Information:*

* * **Intended Use:** This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.

* **Warning:** **This product is not for human or veterinary use.** *

**Legal Status:**

2C-E is strictly controlled under international law. In the United States, it is classified as a Schedule I Controlled Substance. Procurement of the bulk solid material typically requires DEA registration or a corresponding national permit. However, highly dilute solutions (e.g., 1 mg/mL in methanol) are often formulated and sold as DEA-exempt preparations to qualified diagnostic and forensic laboratories. Handling should only occur within professional laboratory environments using appropriate Personal Protective Equipment (PPE).