4-HO-MiPT (Miprocin)

Product Name: 4-HO-MiPT (4-Hydroxy-N-methyl-N-isopropyltryptamine) Synonyms: Miprocin; 3-[2-(isopropylmethylamino)ethyl]-1H-indol-4-ol; 4-Hydroxy-MiPT; 4-OH-MiPT12

General Description: 4-HO-MiPT is formally described as 3-[2-(methyl(propan-2-yl)amino)ethyl]-1H-indol-4-ol.25 It is a synthetic, psychoactive molecule belonging to the tryptamine class.456 Structurally, 4-HO-MiPT is the N-substituted isopropyl homologue of the naturally occurring psychedelic psilocin (4-HO-DMT), as well as the 4-hydroxy analogue of MiPT.25 First popularized by Alexander Shulgin in his foundational text TiHKAL (Tryptamines I Have Known and Loved), it is noted for exhibiting classic psychedelic properties highly analogous to those of psilocybin mushrooms.25

In analytical, clinical, and forensic toxicology, 4-HO-MiPT is utilized as a reference standard for the calibration of analytical instruments (such as LC-MS/MS, GC-MS, and NMR) and the development of screening methodologies to identify and quantify illicit designer drugs in seized materials or biological matrices.25

Technical Information (Freebase):

• CAS Number: 77872-43-6256
• Molecular Formula: C₁₄H₂₀N₂O24
• Formula Weight: 232.33 g/mol25
• SMILES: CC(C)N(C)CCC1=CNC2=C1C(=CC=C2)O257
• InChI Key: RXKGHZCQFXXWFQ-UHFFFAOYSA-N245
• Formulation: Typically supplied as a neat crystalline solid (often formulated as a fumarate or hydrochloride salt to ensure chemical stability, resistance to oxidation, and accurate dosing) or as a certified reference material solution (e.g., 1 mg/mL in methanol).25

Biological Action: 4-HO-MiPT acts predominantly as a non-selective agonist at central serotonin receptors, exhibiting substantial binding affinity and efficacy at the 5-HT_2A, 5-HT_1A, and 5-HT_2C subtypes.25 The robust activation of the 5-HT_2A receptor primarily mediates its characteristic psychedelic properties and physiological effects.25 Its in vivo pharmacological profile—including onset, duration of action, and behavioral responses—is heavily comparable to that of psilocin.25

Regulatory and Safety Information:

• Intended Use: This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.25
• Warning: This product is not for human or veterinary use.
• Legal Status: The regulatory status of 4-HO-MiPT varies globally.128 In the United Kingdom, it is broadly controlled as a Class A substance under the Misuse of Drugs Act.25 In the United States, 4-HO-MiPT is not explicitly scheduled at the federal level; however, because it is structurally and pharmacologically homologous to the Schedule I substance psilocin (4-HO-DMT), its manufacturing, distribution, or possession can be prosecuted under the Federal Analogue Act if intended for human consumption.25 Several individual jurisdictions and European countries have scheduled it independently.25 Procurement may require relevant local licenses.25 Handling should only occur within professional laboratory environments using appropriate Personal Protective Equipment (PPE) such as safety glasses, chemical-resistant gloves, and a laboratory coa