MDPHP

MDPHP is a methylenedioxy analog of A-PHP for cathinone research. Purity ≥97% (HPLC). For research purposes only.

Product Name: MDPHP (3′,4′-Methylenedioxy-α-pyrrolidinohexiophenone) Synonyms: 3,4-MDPHP; 3′,4′-MD-α-PHP; 1-(1,3-benzodioxol-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one; Monkey Dust (colloquial)123

General Description: MDPHP is formally described as 1-(1,3-benzodioxol-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one.145 It is a synthetic, highly psychoactive molecule belonging to the cathinone class, specifically the pyrrolidinophenone subclass.13 Structurally, it is closely related to the notorious designer drugs MDPV (differing by an extended hexyl side chain instead of a pentyl side chain) and α-PVP (“Flakka”).13 Emerging on the illicit market as a novel psychoactive substance (NPS) to circumvent restrictions on older synthetic cathinones, MDPHP is sought for its extremely potent psychostimulant effects.13 In regions such as the United Kingdom, it has been notoriously associated with the colloquial street name “Monkey Dust.”23

In analytical, clinical, and forensic toxicology, MDPHP is utilized as a fundamental reference standard.13 It is essential for the calibration of analytical instrumentation (such as LC-MS/MS, GC-MS, and HPLC) and the development of screening methodologies to identify and quantify the substance in seized materials, adulterated illicit street drugs, or biological matrices (e.g., whole blood, plasma, urine).13

Technical Information (Hydrochloride Salt):

• CAS Number: 24622-61-5 (Hydrochloride) / 776994-64-0 (Freebase)13
• Molecular Formula: C₁₇H₂₃NO₃16 • HCl
• Formula Weight: 325.8 g/mol (Hydrochloride) / 289.4 g/mol (Freebase)13
• SMILES: CCCCC(N1CCCC1)C(=O)C2=CC3=C(C=C2)OCO3.Cl16
• InChI Key: UDZJNLZRWBOFTK-UHFFFAOYSA-N (Hydrochloride) / OBLFRFGUZZRECT-UHFFFAOYSA-N (Freebase)13
• Formulation: Typically supplied as a neat white-to-off-white crystalline solid or as a certified reference material solution (e.g., 1 mg/mL or 100 µg/mL in methanol).13

Biological Action: Like its structural relatives MDPV and α-PVP, MDPHP acts as a profoundly potent monoamine reuptake inhibitor.13 It selectively and aggressively blocks the dopamine transporter (DAT) and the norepinephrine transporter (NET), while exhibiting negligible affinity for the serotonin transporter (SERT).13 This massive accumulation of dopamine and norepinephrine in the synaptic cleft mediates its intense stimulatory effects.13 The clinical presentation of acute MDPHP intoxication includes intense euphoria, severe tachycardia, hypertension, hyperthermia, extreme agitation, and a notably high propensity for inducing prolonged stimulant psychosis, severe paranoia, and excited delirium.13

Regulatory and Safety Information:

• Intended Use: This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.13
• Warning: This product is an exceptionally potent psychostimulant and carries a severe risk of intense psychological dependence, acute psychiatric crises, cardiovascular collapse, and potentially fatal overdose.13 It is not for human or veterinary use.13
• Legal Status: MDPHP is heavily restricted globally.13 In the United Kingdom, it is controlled as a Class B substance under the Misuse of Drugs Act 1971.13 In Canada, it is a Schedule I controlled substance.23 In the United States, MDPHP is not explicitly scheduled at the federal level; however, due to its close structural and pharmacological homology to the Schedule I substance MDPV, its manufacturing, distribution, or possession can be aggressively prosecuted under the Federal Analogue Act if intended for human consumption.13 Several individual U.S. states and European nations (such as Germany and Sweden) have proactively scheduled it.13 Procurement may require relevant local or institutional licenses.13 Handling should only occur within professional laboratory environments using appropriate Personal Protective Equipment (PPE) such as safety glasses, chemical-resistant gloves, and a laboratory coat.1