Butyrfentanyl 100ML

Product Name: Butyrfentanyl Synonyms: Butyryl fentanyl; Butyr fentanyl; NIH 10486; N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]butanamide123

General Description: Butyrfentanyl is formally described as N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]butanamide.123 It is a highly potent, short-acting synthetic opioid analgesic belonging to the 4-anilidopiperidine class.124 Structurally, it is a designer analogue of fentanyl wherein the N-propionyl group has been replaced by an N-butyryl (butanamide) group.124

In analytical, clinical, and forensic toxicology, butyrfentanyl is utilized as a fundamental reference standard.124 It is essential for the calibration of analytical instrumentation (such as LC-MS/MS and GC-MS) and the development of screening methodologies to identify and quantify the substance in seized materials, adulterated illicit street drugs, or biological matrices (e.g., whole blood, urine).124

Technical Information (Hydrochloride Salt):

• CAS Number: 1443-52-3 (Hydrochloride) / 1169-70-6 (Freebase)124
• Molecular Formula: C₂₃H₃₀N₂O134 • HCl
• Formula Weight: 387.0 g/mol123
• SMILES: O=C(CCC)N(C1CCN(CCC2=CC=CC=C2)CC1)C3=CC=CC=C3.Cl124
• InChI Key: OHCXSXCINRZXIB-UHFFFAOYSA-N123
• Formulation: Typically supplied as a neat crystalline solid or as a certified reference material solution (e.g., 1 mg/mL or 100 µg/mL in methanol).124

Biological Action: Butyrfentanyl acts as a potent, short-acting agonist primarily at the μ-opioid receptor (MOR).124 Preclinical in vitro binding assays indicate that its receptor affinity and functional potency are lower than that of fentanyl (approximately one-quarter the potency), yet it remains profoundly active.124 Its pharmacological profile includes deep analgesia, sedation, miosis, euphoria, and potentially fatal respiratory depression.124 Due to its high lipophilicity, it readily crosses the blood-brain barrier, resulting in a rapid onset of action similar to that of fentanyl.124

Regulatory and Safety Information:

• Intended Use: This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.124
• Warning: This product is highly toxic and carries a severe risk of fatal overdose.124 It is not for human or veterinary use.236
• Legal Status: Butyrfentanyl is strictly controlled under international law (Single Convention on Narcotic Drugs).124 In the United States, it is classified as a Schedule I Controlled Substance.234 Procurement of bulk solid material requires an active Drug Enforcement Administration (DEA) registration or an equivalent national license.24 However, highly dilute solutions are often formulated and sold as DEA-exempt preparations to qualified diagnostic and forensic laboratories.124 Extreme caution and stringent safety protocols must be observed; handling should only occur within professional laboratory environments (e.g., inside a certified fume hood or isolator) using extensive Personal Protective Equipment (PPE) to prevent accidental inhalation, ingestion, or dermal exposure