Isohexen (N-Ethylpentylone)

Isohexen (N-Ethylpentylone)

N-Ethylpentylone (Isohexen) is a synthetic cathinone for research purposes. Purity ≥97% (HPLC).

1. Isohexen (N-Ethylisohexedrone)1

Product Name: Isohexen (N-Ethylisohexedrone) Synonyms: NEiH; HEiXEN; N-Ethyl-iso-hexedrone; 2-(ethylamino)-4-methyl-1-phenylpentan-1-one; Iso-Hexen1

General Description: Isohexen is formally described as 2-(ethylamino)-4-methyl-1-phenylpentan-1-one.1 It is a synthetic, psychoactive molecule belonging to the substituted cathinone class.1 Structurally, it is a branched-chain isomer of the well-known designer drug N-ethylhexedrone (Hexen), differing by the presence of an isobutyl group (a 4-methylpentyl framework) rather than a straight hexyl chain.1 It emerged on the illicit designer drug market in the 2020s as a novel psychoactive substance (NPS) intended to circumvent international legislation controlling straight-chain synthetic cathinones like Hexen and N-ethylpentedrone (NEP).1

In analytical and forensic toxicology, Isohexen is utilized as a reference standard for the calibration of analytical instrumentation and the development of screening methodologies to identify the substance in seized materials or biological matrices.1

Technical Information (Hydrochloride Salt):

• CAS Number: N/A (Due to its recent emergence as a novel research chemical, a definitive CAS registry number may not be universally established across all databases).1
• Molecular Formula: C₁₄H₂₁NO1 • HCl
• Formula Weight: 255.8 g/mol (Hydrochloride salt) / 219.33 g/mol (Freebase)1
• SMILES: CC(C)CC(NCC)C(=O)C1=CC=CC=C1.Cl1
• Formulation: Typically supplied as a neat white-to-off-white crystalline powder or as a certified reference material solution.1

Biological Action: Like its straight-chain counterpart Hexen, Isohexen is presumed to act primarily as a potent monoamine reuptake inhibitor.1 It predominantly targets the dopamine transporter (DAT) and norepinephrine transporter (NET), preventing the clearance of these neurotransmitters from the synaptic cleft.1 This rapid accumulation of catecholamines heavily mediates its psychomotor stimulant, euphoric, and tachycardic effects.1

Regulatory and Safety Information:

• Intended Use: This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.11
• Warning: This product is an uncharacterized, potent psychostimulant and carries a significant risk of cardiovascular stress, psychiatric complications, and physiological dependence.1 It is not for human or veterinary use.11
• Legal Status: The regulatory status of Isohexen varies globally.1 While it may not be explicitly scheduled by name at the federal level in the United States, due to its close structural and pharmacological homology to controlled synthetic cathinones, its manufacturing, distribution, or possession can be aggressively prosecuted under the Federal Analogue Act if intended for human consumption.1 It is frequently subject to blanket bans targeting cathinone derivatives in numerous European jurisdictions.1 Procurement may require relevant local licenses.1 Handling should only occur within professional laboratory environments using appropriate Personal Protective Equipment (PPE).1