5-MeO-DiPT (Foxy)

5-MeO-DiPT (Foxy) Product Name

:** 5-MeO-DiPT (5-Methoxy-N,N-diisopropyltryptamine)

**Synonyms:** Foxy; Foxy Methoxy; 5-Methoxy-DiPT; 5-methoxy-N,N-bis(1-methylethyl)-1H-indole-3-ethanamine **General

Description:** 5-MeO-DiPT is formally described as N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N-(propan-2-yl)propan-2-amine. It is a synthetic, psychoactive molecule belonging to the tryptamine class. Known colloquially as “Foxy” or “Foxy Methoxy,” it is structurally related to other ring-substituted designer tryptamines such as 5-MeO-MiPT and DiPT. First popularized in Alexander Shulgin’s foundational text *TiHKAL*, 5-MeO-DiPT is characterized by a unique profile of auditory distortions, entactogenic properties, and psychedelic effects. In analytical, clinical, and forensic toxicology, 5-MeO-DiPT is utilized as a fundamental reference standard. It is essential for the calibration of analytical instrumentation (such as LC-MS/MS, GC-MS, and NMR) and the development of screening methodologies to identify and quantify the substance in seized materials, urine drug screens, or other biological matrices.

**Technical Information (Freebase):** *

**CAS Number:** 4021-34-5 *

**Molecular Formula:** C₁₇H₂₆N₂O *

**Formula Weight:** 274.40 g/mol * **SMILES:** CC(C)N(C(C)C)CCC1=CNC2=C1C=C(OC)C=C2 * **InChI Key:** DNBPMBJFRRVTSJ-UHFFFAOYSA-N *
**Formulation:** Typically supplied as a neat crystalline solid (sometimes formulated as a hydrochloride salt to ensure stability and increased water solubility) or as a certified reference material solution (e.g., 1 mg/mL in methanol).

**Biological Action:** 5-MeO-DiPT acts as an agonist at central serotonin receptors, exhibiting notable binding affinity and efficacy at the 5-HT_1A, 5-HT_2A, and 5-HT_2C subtypes. The activation of the 5-HT_2A receptor primarily mediates its psychedelic properties. Furthermore, *in vitro* assays indicate that 5-MeO-DiPT acts as a potent inhibitor of monoamine reuptake—specifically inhibiting the serotonin transporter (SERT) and, to a lesser extent, the norepinephrine transporter (NET) and dopamine transporter (DAT)—without significantly promoting monoamine release. This robust reuptake inhibition heavily contributes to its characteristic entactogenic and physiological effects.

**Regulatory and Safety Information:**

* **Intended Use:** This product is intended strictly for use as an analytical reference standard for forensic, toxicological, and academic research purposes.

* **Warning:**

**This product is not for human or veterinary use.**

* **Legal Status:** 5-MeO-DiPT is strictly controlled in many jurisdictions globally. In the United States, it was placed into Schedule I of the Controlled Substances Act in 2004. Procurement of bulk solid material requires active Drug Enforcement Administration (DEA) registration or an equivalent national license. However, highly dilute solutions (e.g., 1 mg/mL in methanol) are often formulated and sold as DEA-exempt preparations to qualified diagnostic and forensic laboratories. Handling should only occur within professional laboratory environments using appropriate Personal Protective Equipment (PPE) such as safety glasses, chemical-resistant gloves, and a laboratory coat.